Found 52 matching trials
PolyImmune {Durvalumab (MEDI4736) and Tremelimumab} & Vaccine Orchestrated Treatment for Patients With Advanced/Metastatic Renal Cell Carcinoma PHASE2 Reported in the 2018 NEJM (378; 1277) article, the combination of checkpoin...
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Multiple Locations
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Programmed Cell Death 1 + Selected Cell Therapy With Durvalumab (MEDI4736) and Tremelimumab in Metastatic Melanoma EARLY_PHASE1 The primary objective of this pilot study is to assess the feasibility of m...
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Multiple Locations
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Phase II Study of MEDI4736, Tremelimumab, and MEDI4736 in Combination w/ Tremelimumab Squamous Cell Carcinoma of the Head and Neck PHASE2 The purpose of this study is to determine the efficacy and safety of invest...
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Study of Durvalumab + Tremelimumab With Chemotherapy or Durvalumab With Chemotherapy or Chemotherapy Alone for Patients With Lung Cancer (POSEIDON). PHASE3 This is a randomized, open-label, multi-center, global, Phase III study to ...
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Active Not Recruiting
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Radiotherapy With Double Checkpoint Blockade of Locally Advanced HNSCC PHASE2 First-line treatment of locally advanced HNSCC with double checkpoint block...
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Klinik Chemnitz gGmbH
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Phase 1 Study to Evaluate MEDI4736 in Subjects With Myelodysplastic Syndrome PHASE1 This is a multicenter, open-label, Phase 1 study to assess the safety and a...
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A Phase 1b/2 Safety and Tolerability Study of MEDI6469 in Combination With Therapeutic Immune Agents or Monoclonal Antibodies PHASE1 The main purpose of this study is to determine the best dose of MEDI6469 th...
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Durvalumab With or Without Tremelimumab in Resectable Locally Advanced Squamous Cell Carcinoma of the Oral Cavity PHASE1 This is a randomized, open-label, prospective, pilot phase I/II study with ...
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Microbiome Immunotherapy Toxicity and Response Evaluation N/A This is a observational study to investigate how the microbiome correlates ...
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Royal United Hospitals Bath NHS Foundation Trust
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A Global Study to Assess the Effects of MEDI4736 (Durvalumab), Given as Monotherapy or in Combination With Tremelimumab Determined by PD-L1 Expression Versus Standard of Care in Patients With Locally Advanced or Metastatic Non Small Cell Lung Cancer PHASE3 This study is a Phase III, randomised, open label, multi-centre study asses...
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